KCTD9

Across TCGA patient cohorts, KCTD9 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD9-associated genes across cancer lineages are Akt_pT308, EGFR_pY1068, and Fibronectin. Each is linked with KCTD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD9-to-partner and partner-to-KCTD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by KCTD9-low versus KCTD9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD9→partner) and Y-score (partner→KCTD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.497	+1.765	.035	.014	3	2
UCEC	EGFR_pY1068 →	-0.242	-2.169	.010	.003	3	1
UCEC	Fibronectin →	-0.283	-1.765	.022	.014	3	1
UCEC	ACC_pS79 →	+0.381	+3.321	.003	.009	3	1
UCEC	IGFBP2 →	-0.633	-1.765	.009	.014	3	1
UCEC	INPP4B →	-0.350	-2.906	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Akt_pT308 by KCTD9 expression — UCEC

Explore this box plot interactively →