Across TCGA pan-cancer cohorts, KCTD8 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KCTD8 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KCTD8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCTD8 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCEC show a favorable association.

HNSC, ESCA, and LUSC are the cancer types where KCTD8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.156	0.711	.007	18	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
LUSC	OS	Median	All	0.805	0.370	.013	3	view →
UCEC	DFS	Median	II,III,IV	0.915	0.441	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KCTD8 tumor-vs-normal RNA expression · all KCTD8 data types