Across TCGA patient cohorts, KCTD8 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,450 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KCTD8-associated proteins across cancer lineages are STXBP1, CAVIN2_S203, and GUCY1B1. Each is linked with KCTD8 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCTD8-to-partner and partner-to-KCTD8 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD8→partner) and Y-score (partner→KCTD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STXBP1 →	+0.835	+0.787	<.001	<.001	3	4
UCEC	CAVIN2_S203 →	+0.616	+0.445	<.001	.001	3	4
UCEC	GUCY1B1 →	+0.461	+0.425	<.001	.002	3	4
UCEC	COL15A1 →	+0.851	+0.598	<.001	<.001	3	4
COAD	GNAO1 →	+0.578	+0.073	<.001	<.001	3	4
UCEC	ANK2 →	+0.402	+0.406	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,450 associations by consensus.

Exploration

KCTD8 survival (RNA) · tumor vs normal (RNA) · all KCTD8 data types