Across TCGA patient cohorts, KCTD8 protein abundance is significantly associated with the RNA expression of many other genes, with 4,551 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KCTD8-associated genes across cancer lineages are CBX7, RUNDC3B, and CRHR2. Each is linked with KCTD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD8-to-partner and partner-to-KCTD8 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD8→partner) and Y-score (partner→KCTD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CBX7 →	+0.824	+1.167	<.001	<.001	3	2
UCEC	RUNDC3B →	+0.995	+1.167	<.001	<.001	3	2
UCEC	CRHR2 →	+1.218	+1.396	.002	<.001	3	2
GBM	ASPA →	+0.851	+0.531	<.001	<.001	3	2
GBM	SEPTIN4 →	+0.926	+0.603	<.001	<.001	3	2
UCEC	HLF →	+1.720	+1.434	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,551 associations by consensus.

Exploration

KCTD8 survival (RNA) · tumor vs normal (RNA) · all KCTD8 data types