Across TCGA patient cohorts, KCTD8 mutation is significantly associated with the RNA expression of many other genes, with 3,751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD8-associated genes across cancer lineages are ERP27, ENO1, and MYO19. Each is linked with KCTD8 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCTD8-to-partner and partner-to-KCTD8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD8→partner) and Y-score (partner→KCTD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ERP27 →	-1.046	-3.682	<.001	.001	3	4
UCEC	ENO1 →	+0.449	+2.753	.002	<.001	3	4
LUAD	MYO19 →	+0.465	+2.415	.004	.003	3	3
STAD	H3P1 →	+0.635	+3.203	<.001	.009	3	3
UCEC	CDKN3 →	+0.588	+2.061	.001	<.001	3	3
UCEC	AHSA1 →	+0.337	+3.151	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,751 associations by consensus.

Exploration

KCTD8 survival (RNA) · tumor vs normal (RNA) · all KCTD8 data types