KCTD8

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KCTD8 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD8-associated genes across cancer lineages are EGFR_pY1068, ERCC1, and ACC_pS79. Each is linked with KCTD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCTD8-to-partner and partner-to-KCTD8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD8→partner) and Y-score (partner→KCTD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECEGFR_pY1068 →-0.189-1.847.017.00733
UCECERCC1 →-0.121-3.673.026.00132
UCECACC_pS79 →+0.247+2.000.023.02932
UCECNotch1 →+0.175+2.515<.001<.00132
UCECPRAS40_pT246 →+0.143+2.087.008.00532
UCECSTAT3_pY705 →-0.298-1.836<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration