KCTD7

Across TCGA patient cohorts, KCTD7 mutation is significantly associated with the RNA expression of many other genes, with 551 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD7-associated genes across cancer lineages are RNU6-763P, SS18L2P1, and CHAF1A. Each is linked with KCTD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD7-to-partner and partner-to-KCTD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-763P grouped by KCTD7-low versus KCTD7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD7→partner) and Y-score (partner→KCTD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-763P →	+0.149	+4.485	<.001	.004	3	2
LUSC	SS18L2P1 →	+0.276	+5.031	<.001	.002	3	2
UCEC	CHAF1A →	+0.546	+2.021	.003	.005	3	2
SKCM	NCAPH2 →	+0.626	+3.227	.002	.009	3	2
UCEC	IL21 →	+0.120	+1.737	.001	.007	3	2
UCEC	IGKJ5 →	+2.113	+3.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 551 associations by consensus.

RNU6-763P by KCTD7 expression — SKCM

Explore this box plot interactively →