KCTD7

Across TCGA patient cohorts, KCTD7 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD7-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and GATA6. Each is linked with KCTD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD7-to-partner and partner-to-KCTD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KCTD7-low versus KCTD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD7→partner) and Y-score (partner→KCTD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.277	-2.222	.009	.011	3	1
UCEC	eIF4E →	+0.235	+3.183	.008	.009	3	1
UCEC	GATA6 →	-0.192	-2.985	.004	.034	3	1
UCEC	Heregulin →	-0.181	-2.308	<.001	.033	3	1
UCEC	IGFBP2 →	-0.583	-1.700	.034	.044	3	1
UCEC	JNK2 →	+0.284	+2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by KCTD7 expression — UCEC

Explore this box plot interactively →