KCTD6

Across TCGA pan-cancer cohorts, KCTD6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCTD6 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KCTD6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KCTD6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where KCTD6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.769	.002	27	view →
UCEC	OS	Median	III,IV	0.494	1.000	.016	26	view →
HNSC	OS	Median	III,IV	0.959	0.707	.003	22	view →
LSCC	OS	Median	All	0.690	1.000	.014	7	view →
GBM	DFS	Quartile	All	0.538	0.248	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCTD6–CCRCC (OS)

Open the CCRCC breakdown →