KCTD6

Across TCGA patient cohorts, KCTD6 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD6-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and eIF4E. Each is linked with KCTD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD6-to-partner and partner-to-KCTD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by KCTD6-low versus KCTD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD6→partner) and Y-score (partner→KCTD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.330	-1.584	.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.224	-1.584	.023	.036	3	1
UCEC	eIF4E →	+0.171	+3.013	.038	.018	3	1
UCEC	ACVRL1 →	+0.127	+2.000	.017	.010	3	1
UCEC	JNK2 →	+0.239	+2.009	.002	.017	3	1
UCEC	MSH2 →	-0.216	-3.143	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

STAT3_pY705 by KCTD6 expression — UCEC

Explore this box plot interactively →