KCTD5

Across TCGA patient cohorts, KCTD5 mutation is significantly associated with the RNA expression of many other genes, with 961 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD5-associated genes across cancer lineages are MTND5P35, RNA5SP443, and KRTAP20-3. Each is linked with KCTD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD5-to-partner and partner-to-KCTD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P35 grouped by KCTD5-low versus KCTD5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD5→partner) and Y-score (partner→KCTD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTND5P35 →	+0.035	+5.539	<.001	.004	3	2
UCEC	RNA5SP443 →	+0.264	+2.522	<.001	.001	3	2
UCEC	KRTAP20-3 →	+0.064	+3.973	<.001	.006	3	2
UCEC	MTCO1P35 →	+0.415	+2.714	<.001	.004	3	2
UCEC	YTHDF3-AS1 →	+0.757	+3.491	<.001	.002	3	1
UCEC	CWC25 →	+0.396	+3.753	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 961 associations by consensus.

MTND5P35 by KCTD5 expression — CESC

Explore this box plot interactively →