KCTD5

Across TCGA patient cohorts, KCTD5 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD5-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and Fibronectin. Each is linked with KCTD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD5-to-partner and partner-to-KCTD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KCTD5-low versus KCTD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD5→partner) and Y-score (partner→KCTD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.224	-2.000	.047	.032	3	1
UCEC	eIF4G →	+0.281	+2.700	.045	.006	3	1
UCEC	Fibronectin →	-0.303	-2.000	.041	.032	3	1
UCEC	Heregulin →	-0.154	-2.700	.005	.006	3	1
UCEC	JNK2 →	+0.223	+2.817	.012	.036	3	1
UCEC	N-Ras →	-0.127	-1.986	.017	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by KCTD5 expression — UCEC

Explore this box plot interactively →