KCTD3

Across TCGA pan-cancer cohorts, KCTD3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCTD3 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KCTD3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KCTD3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where KCTD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.560	0.825	.015	15	view →
UCEC	OS	Tertile	All	1.000	0.860	.020	12	view →
LUAD	DFS	Tertile	II,III,IV	0.217	0.781	.018	8	view →
PDAC	OS	Median	II,III,IV	0.451	0.593	.030	7	view →
LSCC	DFS	Median	III,IV	0.858	1.000	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCTD3–CCRCC (OS)

Open the CCRCC breakdown →