KCTD3

Across TCGA patient cohorts, KCTD3 mutation is significantly associated with the RNA expression of many other genes, with 3,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD3-associated genes across cancer lineages are SAP30, PLRG1, and PKM. Each is linked with KCTD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCTD3-to-partner and partner-to-KCTD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAP30 grouped by KCTD3-low versus KCTD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD3→partner) and Y-score (partner→KCTD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAP30 →	+0.641	+2.021	<.001	<.001	3	3
UCEC	PLRG1 →	+0.464	+3.928	<.001	<.001	3	3
UCEC	PKM →	+0.461	+1.999	<.001	<.001	3	3
UCEC	BIRC5 →	+0.609	+1.787	.002	<.001	3	3
UCEC	UFSP2 →	+0.398	+2.436	<.001	.001	3	3
UCEC	PDHX →	+0.495	+1.819	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,900 associations by consensus.

SAP30 by KCTD3 expression — UCEC

Explore this box plot interactively →