Across TCGA patient cohorts, KCTD21 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD21-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with KCTD21 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD21-to-partner and partner-to-KCTD21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD21→partner) and Y-score (partner→KCTD21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.406	+1.807	.005	.027	3	1
UCEC	EGFR_pY1068 →	-0.313	-2.807	.002	.003	3	1
UCEC	eIF4E →	+0.211	+3.584	.015	.002	3	1
UCEC	A-Raf_pS299 →	-0.120	-2.999	.015	.035	3	1
UCEC	GAPDH →	+0.616	+3.321	.005	.009	3	1
UCEC	MEK1 →	+0.478	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

KCTD21 survival (RNA) · tumor vs normal (RNA) · all KCTD21 data types