Across TCGA cell cohorts, KCTD21 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. CNS shows the largest number of these associations.

The most reproducible KCTD21-associated genes across cancer lineages are MSGN1, IL17A, and MS4A2. Each is linked with KCTD21 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD21-to-partner and partner-to-KCTD21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD21→partner) and Y-score (partner→KCTD21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
CNS	IL17A →	+0.010	+5.357	<.001	.001	3	1
CNS	MS4A2 →	+0.021	+4.169	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

KCTD21 survival (RNA) · tumor vs normal (RNA) · all KCTD21 data types