KCTD19

Across TCGA patient cohorts, KCTD19 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD19-associated genes across cancer lineages are JNK2, MEK1, and p90 RSK_pT359_S363. Each is linked with KCTD19 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD19-to-partner and partner-to-KCTD19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by KCTD19-low versus KCTD19-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD19→partner) and Y-score (partner→KCTD19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JNK2 →	+0.219	+2.178	.012	.035	3	2
UCEC	MEK1 →	+0.234	+1.584	.045	.017	3	2
COAD	p90 RSK_pT359_S363 →	-0.196	-3.313	.019	.010	3	2
UCEC	14-3-3_beta →	-0.091	-2.195	.004	.009	3	2
UCEC	IGFBP2 →	-0.628	-1.289	.002	.023	3	2
UCEC	p27_pT198 →	+0.085	+2.222	.012	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

JNK2 by KCTD19 expression — COAD

Explore this box plot interactively →