Across TCGA pan-cancer cohorts, KCTD16 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KCTD16’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where KCTD16 RNA is repressed in tumor relative to normal tissue. In most cancer types KCTD16 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, THCA, and LUSC are the cancer types where KCTD16 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCTD16 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.