KCTD15

Across TCGA pan-cancer cohorts, KCTD15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCTD15 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KCTD15 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCTD15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where KCTD15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.152	0.891	.001	26	view →
HNSC	DFS	Median	All	1.000	0.393	.018	6	view →
LSCC	DFS	Median	All	0.833	0.610	.011	6	view →
LUAD	OS	Median	III,IV	0.612	0.995	.036	5	view →
GBM	DFS	Quartile	All	0.460	0.229	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCTD15–PDAC (DFS)

Open the PDAC breakdown →