KCTD14

Across TCGA pan-cancer cohorts, KCTD14 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KCTD14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KCTD14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCTD14 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

COAD, LUSC, and KICH are the cancer types where KCTD14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCTD14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.616	<.001	11	view →
LUSC	All	III,IV	−1.943	<.001	9	view →
KICH	All	All	−1.044	<.001	8	view →
BRCA	Female	II,III,IV	−2.142	<.001	6	view →
READ	All	All	+0.731	<.001	3	view →
PRAD	All	All	−1.369	<.001	2	view →
UCEC	All	All	+1.056	.013	2	view →
THCA	Male	All	+0.359	.006	2	view →
KIRC	Male	All	+0.306	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

KCTD14–COAD

Open the COAD breakdown →