KCTD14

Across TCGA pan-cancer cohorts, KCTD14 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KCTD14’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where KCTD14 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types KCTD14 is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, COAD, and PDAC are the cancer types where KCTD14 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCTD14 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	II,III,IV	−1.590	<.001	9	view →
COAD	Female	All	+0.502	<.001	9	view →
PDAC	Female	All	−1.744	<.001	7	view →
LUAD	Female	III,IV	−1.095	<.001	7	view →
CCRCC	Male	All	+0.698	<.001	7	view →
HNSC	All	II,III,IV	−0.559	.020	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KCTD14–LSCC

Open the LSCC breakdown →