KCTD12

Across TCGA pan-cancer cohorts, KCTD12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KCTD12 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KCTD12 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KCTD12 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where KCTD12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.984	0.754	.006	18	view →
LUAD	DFS	Tertile	All	0.832	0.443	<.001	17	view →
HNSC	DFS	Quartile	II,III,IV	0.892	1.000	.017	14	view →
UCEC	OS	Median	II,III,IV	0.609	1.000	.008	8	view →
CCRCC	DFS	Quartile	III,IV	0.140	0.887	.038	6	view →
LSCC	DFS	Tertile	II,III,IV	0.865	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KCTD12–PDAC (OS)

Open the PDAC breakdown →