KCTD12

Across TCGA patient cohorts, KCTD12 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD12-associated genes across cancer lineages are ACC1, Ku80, and Annexin-1. Each is linked with KCTD12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD12-to-partner and partner-to-KCTD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by KCTD12-low versus KCTD12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD12→partner) and Y-score (partner→KCTD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.506	+2.321	.005	.035	3	1
UCEC	Ku80 →	+0.289	+2.817	.015	.036	3	1
UCEC	Annexin-1 →	+0.596	+2.827	.024	.035	3	1
UCEC	VHL →	-1.233	-2.321	<.001	.035	3	1
UCEC	Di-Ras3 →	-0.161	-2.321	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ACC1 by KCTD12 expression — UCEC

Explore this box plot interactively →