Across TCGA patient cohorts, KCTD11 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD11-associated genes across cancer lineages are Caspase-7-cleavedD198, FOXO3a, and ACC1. Each is linked with KCTD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD11-to-partner and partner-to-KCTD11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD11→partner) and Y-score (partner→KCTD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.812	+2.341	.004	.019	3	2
UCEC	FOXO3a →	-0.122	-2.970	.013	.036	3	1
UCEC	ACC1 →	+0.525	+2.321	.002	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-3.169	.009	.019	3	1
UCEC	MSH6 →	-0.460	-2.459	.003	.020	3	1
UCEC	mTOR_pS2448 →	-0.195	-2.986	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

KCTD11 survival (RNA) · tumor vs normal (RNA) · all KCTD11 data types