KCTD10

Across TCGA pan-cancer cohorts, KCTD10 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KCTD10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KCTD10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCTD10 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where KCTD10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCTD10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.559	<.001	11	view →
LIHC	Female	II,III,IV	+1.170	<.001	9	view →
THCA	Male	III,IV	−1.054	<.001	9	view →
LUAD	Female	III,IV	−0.718	<.001	8	view →
LUSC	All	II,III,IV	−0.559	<.001	8	view →
KICH	All	All	−0.719	<.001	7	view →
BLCA	Male	All	−0.804	.002	6	view →
BRCA	All	All	−0.425	<.001	6	view →
CHOL	Male	All	+2.374	<.001	3	view →
KIRC	All	All	+0.326	<.001	3	view →
COAD	Male	All	−0.313	.012	3	view →
UCEC	All	All	−0.826	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KCTD10–HNSC

Open the HNSC breakdown →