Across TCGA pan-cancer cohorts, KCNU1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KCNU1’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where KCNU1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNU1 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.
LIHC, LUAD, and LUSC are the cancer types where KCNU1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNU1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.