KCNT2

Across TCGA patient cohorts, KCNT2 mutation is significantly associated with the RNA expression of many other genes, with 5,800 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNT2-associated genes across cancer lineages are MEX3D, CORO2B, and DDX39A. Each is linked with KCNT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNT2-to-partner and partner-to-KCNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEX3D grouped by KCNT2-low versus KCNT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNT2→partner) and Y-score (partner→KCNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEX3D →	+0.594	+1.678	<.001	<.001	3	5
UCEC	CORO2B →	-0.463	-2.796	<.001	<.001	3	4
LUAD	DDX39A →	+0.327	+2.380	.002	<.001	3	4
UCEC	SKA1 →	+0.644	+1.525	<.001	<.001	3	4
LUAD	MAMDC2 →	-0.824	-3.236	<.001	<.001	3	4
UCEC	IFRD1 →	+0.433	+1.514	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,800 associations by consensus.

MEX3D by KCNT2 expression — UCEC

Explore this box plot interactively →