KCNT2

Across TCGA patient cohorts, KCNT2 mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNT2-associated genes across cancer lineages are cIAP, INPP4B, and Annexin-1. Each is linked with KCNT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNT2-to-partner and partner-to-KCNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by KCNT2-low versus KCNT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNT2→partner) and Y-score (partner→KCNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	cIAP →	+0.105	+2.866	.036	.001	3	4
UCEC	INPP4B →	-0.273	-2.459	.001	<.001	3	4
UCEC	Annexin-1 →	+0.393	+1.493	.003	.003	3	4
LUAD	p70-S6K →	+0.144	+1.999	.038	.029	3	3
UCEC	PCNA →	+0.167	+1.836	.002	.001	3	3
COAD	PKC-b-II_pS660 →	-0.305	-1.874	.028	.049	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

cIAP by KCNT2 expression — COAD

Explore this box plot interactively →