KCNS3

Across TCGA patient cohorts, KCNS3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNS3-associated genes across cancer lineages are Caspase-7-cleavedD198, HER2, and p62 Lck ligand. Each is linked with KCNS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNS3-to-partner and partner-to-KCNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KCNS3-low versus KCNS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNS3→partner) and Y-score (partner→KCNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.535	+2.720	.012	.003	3	3
SKCM	HER2 →	+0.297	+3.321	.043	.010	3	3
UCEC	p62 Lck ligand →	+0.410	+3.584	<.001	.002	3	2
UCEC	Paxillin →	+0.210	+1.925	.024	.005	3	2
UCEC	PDCD4 →	-0.432	-1.700	.010	.040	3	2
UCEC	BRD4 →	+0.286	+3.700	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by KCNS3 expression — UCEC

Explore this box plot interactively →