KCNS3

Across TCGA cell cohorts, KCNS3 mutation is significantly associated with the mutation status of many other genes, with 1,451 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNS3-associated genes across cancer lineages are TMEM67, MAPK12, and KCNH6. Each is linked with KCNS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNS3-to-partner and partner-to-KCNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM67 grouped by KCNS3-low versus KCNS3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNS3→partner) and Y-score (partner→KCNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM67 →	+4.145	+4.635	.001	.001	1	3
BLOOD_Lymphoma	MAPK12 →	+4.832	+4.832	<.001	<.001	1	3
LARGE_INTESTINE	KCNH6 →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	WDR59 →	+2.936	+4.471	.001	.001	1	3
LARGE_INTESTINE	DGKB →	+2.744	+4.321	.002	.002	1	3
BLOOD_Leukemia	KLK2 →	+5.560	+4.736	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,451 associations by consensus.

TMEM67 by KCNS3 expression — BLOOD_Leukemia

Explore this box plot interactively →