KCNS2

Across TCGA patient cohorts, KCNS2 mutation is significantly associated with the RNA expression of many other genes, with 3,855 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNS2-associated genes across cancer lineages are KNL1, KIF2C, and DTL. Each is linked with KCNS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNS2-to-partner and partner-to-KCNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNL1 grouped by KCNS2-low versus KCNS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNS2→partner) and Y-score (partner→KCNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KNL1 →	+0.646	+3.611	<.001	.001	3	3
UCEC	KIF2C →	+0.697	+2.332	<.001	<.001	3	3
UCEC	DTL →	+0.635	+2.595	<.001	<.001	3	3
UCEC	BUB1B →	+0.611	+2.061	.001	<.001	3	3
UCEC	IDH3A →	+0.398	+1.660	.004	.003	3	3
UCEC	MCM10 →	+0.665	+2.483	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,855 associations by consensus.

KNL1 by KCNS2 expression — COAD

Explore this box plot interactively →