KCNS2

Across TCGA patient cohorts, KCNS2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNS2-associated genes across cancer lineages are A-Raf_pS299, INPP4B, and TIGAR. Each is linked with KCNS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNS2-to-partner and partner-to-KCNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by KCNS2-low versus KCNS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNS2→partner) and Y-score (partner→KCNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.153	-1.765	<.001	.013	3	2
COAD	INPP4B →	-0.290	-1.874	.028	.047	3	2
COAD	TIGAR →	+0.312	+1.593	.026	.022	3	2
COAD	Caspase-7-cleavedD198 →	+1.196	+2.807	<.001	.003	3	2
COAD	Chk1 →	+0.168	+1.593	.033	.022	3	2
UCEC	Notch1 →	+0.156	+2.424	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

A-Raf_pS299 by KCNS2 expression — UCEC

Explore this box plot interactively →