KCNS2

Across TCGA cell cohorts, KCNS2 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNS2-associated genes across cancer lineages are IL2, PRAMEF10, and OR1D4. Each is linked with KCNS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNS2-to-partner and partner-to-KCNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by KCNS2-low versus KCNS2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNS2→partner) and Y-score (partner→KCNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL2 →	+0.033	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	PRAMEF10 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1D4 →	+0.031	+4.078	<.001	.009	3	1
LUNG_SCLC	ASZ1 →	+0.064	+5.169	<.001	<.001	3	1
LUNG_SCLC	C5orf52 →	+0.052	+4.643	<.001	.004	3	1
LUNG_SCLC	OR52B4 →	+0.017	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

IL2 by KCNS2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →