KCNS1

Across TCGA patient cohorts, KCNS1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNS1-associated genes across cancer lineages are p27_pT157, ERK2, and Rad50. Each is linked with KCNS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNS1-to-partner and partner-to-KCNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by KCNS1-low versus KCNS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNS1→partner) and Y-score (partner→KCNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p27_pT157 →	+0.200	+2.815	.012	.036	3	2
UCEC	ERK2 →	+0.231	+3.321	.007	.009	3	2
UCEC	Rad50 →	-0.275	-2.000	.011	.032	3	2
UCEC	Cyclin-B1 →	+0.637	+2.700	.011	.006	3	2
COAD	FASN →	+0.593	+2.815	.005	.036	3	1
COAD	14-3-3_epsilon →	+0.155	+2.849	.027	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p27_pT157 by KCNS1 expression — COAD

Explore this box plot interactively →