KCNS1

Across TCGA cell cohorts, KCNS1 mutation is significantly associated with the RNA expression of many other genes, with 550 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNS1-associated genes across cancer lineages are TMCO2, CCR8, and OR6C70. Each is linked with KCNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNS1-to-partner and partner-to-KCNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO2 grouped by KCNS1-low versus KCNS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNS1→partner) and Y-score (partner→KCNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO2 →	+0.063	+2.347	<.001	.007	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.243	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	LILRA5 →	+0.024	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	ZCCHC13 →	+0.011	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	C9orf92 →	+0.117	+3.628	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 550 associations by consensus.

TMCO2 by KCNS1 expression — LARGE_INTESTINE

Explore this box plot interactively →