KCNQ5-IT1

Across TCGA pan-cancer cohorts, KCNQ5-IT1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KCNQ5-IT1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KCNQ5-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KCNQ5-IT1 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUSC show a favorable association.

COAD, KIRC, and UVM are the cancer types where KCNQ5-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.347	0.628	<.001	138	view →
KIRC	DFS	Tertile	III,IV	0.377	0.691	<.001	105	view →
UVM	DFS	Median	II,III,IV	0.766	0.381	.001	60	view →
UCEC	OS	Tertile	All	0.299	0.715	<.001	60	view →
KIRP	DFS	Tertile	All	0.430	0.810	.001	60	view →
ACC	DFS	Tertile	All	0.137	0.673	.003	48	view →
LUSC	OS	Median	All	0.822	0.700	<.001	43	view →
HNSC	OS	Median	All	0.456	0.738	<.001	43	view →
BLCA	OS	Tertile	IV	0.336	0.626	<.001	36	view →
MESO	OS	Tertile	All	0.379	0.604	.010	36	view →
CESC	DFS	Quartile	All	0.853	0.695	.007	32	view →
LAML	DFS	Quartile	All	0.703	0.424	.004	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KCNQ5-IT1–COAD (OS)

Open the COAD breakdown →