Across TCGA patient cohorts, KCNQ3 mutation is significantly associated with the RNA expression of many other genes, with 6,305 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNQ3-associated genes across cancer lineages are METTL2A, PTMAP5, and FAM177A1. Each is linked with KCNQ3 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNQ3-to-partner and partner-to-KCNQ3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ3→partner) and Y-score (partner→KCNQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	METTL2A →	+0.557	+3.205	.001	.009	3	5
COAD	PTMAP5 →	+0.756	+3.335	<.001	.005	3	4
UCEC	FAM177A1 →	+0.268	+1.546	.001	.002	3	4
UCEC	TYW3 →	+0.376	+1.450	<.001	<.001	3	4
UCEC	FXN →	+0.416	+1.936	<.001	<.001	3	4
UCEC	PRDX3 →	+0.408	+2.040	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,305 associations by consensus.

Exploration

KCNQ3 survival (RNA) · tumor vs normal (RNA) · all KCNQ3 data types