Across TCGA patient cohorts, KCNQ3 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNQ3-associated genes across cancer lineages are Collagen-VI, Bad_pS112, and STAT3_pY705. Each is linked with KCNQ3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNQ3-to-partner and partner-to-KCNQ3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ3→partner) and Y-score (partner→KCNQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Collagen-VI →	-0.353	-2.990	.021	.036	3	3
BRCA	Bad_pS112 →	+0.264	+3.006	.022	.020	3	3
STAD	STAT3_pY705 →	-0.249	-2.321	.008	.032	3	3
UCEC	FoxM1 →	+0.152	+1.157	.035	.014	3	3
UCEC	JNK_pT183_Y185 →	-0.130	-1.514	.005	.014	3	3
UCEC	Ku80 →	+0.287	+2.100	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Exploration

KCNQ3 survival (RNA) · tumor vs normal (RNA) · all KCNQ3 data types