Across TCGA cell cohorts, KCNQ3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,799 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KCNQ3-associated GO terms across cancer lineages are Regulation of proteolysis, Regulation of transforming growth factor beta receptor signaling pathway, and Release of cytochrome c from mitochondria. Each is linked with KCNQ3 in more than 6 cancer types. Because this analysis shows association rather than direction, both KCNQ3-to-partner and partner-to-KCNQ3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ3→partner) and Y-score (partner→KCNQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of proteolysis →	+0.056	+0.775	<.001	.004	3	7
LUNG_NSCLC_LUSC	Regulation of transforming growth factor beta receptor signaling pathway →	+0.059	+1.001	.003	.003	3	6
LUNG_NSCLC_LUAD	Release of cytochrome c from mitochondria →	+0.088	+1.023	<.001	.003	3	6
OVARY	Nuclear envelope organization →	+0.072	+0.997	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Nuclear membrane organization →	+0.055	+1.147	<.001	.002	2	7
LUNG_NSCLC_LUAD	Negative regulation of protein catabolic process →	+0.052	+1.339	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,799 associations by consensus.

Exploration

KCNQ3 survival (RNA) · tumor vs normal (RNA) · all KCNQ3 data types