Across TCGA cell cohorts, KCNQ3 mutation is significantly associated with the RNA expression of many other genes, with 193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNQ3-associated genes across cancer lineages are MS4A10, SCGB3A2, and FOXI2. Each is linked with KCNQ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ3-to-partner and partner-to-KCNQ3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ3→partner) and Y-score (partner→KCNQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MS4A10 →	+0.006	+4.867	<.001	.009	3	1
LUNG_SCLC	SCGB3A2 →	+0.593	+3.256	<.001	.005	3	1
LUNG_SCLC	FOXI2 →	+0.048	+4.058	<.001	.001	3	1
LUNG_SCLC	DPPA3 →	+0.034	+3.684	<.001	.001	3	1
CNS	APOBEC1 →	+0.017	+4.754	<.001	.005	3	1
CNS	LYZL2 →	+0.016	+4.321	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 193 associations by consensus.

Exploration

KCNQ3 survival (RNA) · tumor vs normal (RNA) · all KCNQ3 data types