Across TCGA cell cohorts, KCNQ3 mutation is significantly associated with the mutation status of many other genes, with 4,718 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNQ3-associated genes across cancer lineages are NCKAP5L, CABIN1, and USP19. Each is linked with KCNQ3 in more than 5 cancer types. Because this analysis shows association rather than direction, both KCNQ3-to-partner and partner-to-KCNQ3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ3→partner) and Y-score (partner→KCNQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NCKAP5L →	+4.772	+5.339	.004	.004	1	6
OVARY	CABIN1 →	+3.930	+3.632	.003	.003	1	5
LUNG_NSCLC_LUAD	USP19 →	+4.187	+5.000	.008	.008	1	5
LUNG_SCLC	GTF3C1 →	+3.437	+3.437	.006	.006	1	5
BLOOD_Lymphoma	JARID2 →	+3.162	+4.016	.001	.001	1	5
BLOOD_Leukemia	SVEP1 →	+2.913	+3.432	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,718 associations by consensus.

Exploration

KCNQ3 survival (RNA) · tumor vs normal (RNA) · all KCNQ3 data types