KCNQ2

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KCNQ2 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,225 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KCNQ2-associated proteins across cancer lineages are ARVCF_S335, RUFY3, and ACIN1_S825. Each is linked with KCNQ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ2-to-partner and partner-to-KCNQ2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNQ2 versus ARVCF_S335 in GBM, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ2→partner) and Y-score (partner→KCNQ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMARVCF_S335 →+0.450+1.362.001.00132
GBMRUFY3 →+0.377+1.130<.001<.00132
PDACACIN1_S825 →-0.400-0.155.009.00132
PDACSCG2 →+0.728+0.125<.001<.00132
PDACSCG2_S268 →+0.826+0.133<.001<.00132
PDACSCG3 →+0.859+0.132<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 8,225 associations by consensus.

KCNQ2 vs ARVCF_S335 — GBM

Per-sample scatter of KCNQ2 vs ARVCF_S335 in GBM (Pearson r = 0.36).

Explore this scatter interactively →

Exploration