KCNQ2

Across TCGA patient cohorts, KCNQ2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,685 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KCNQ2-associated genes across cancer lineages are MXRA5, BSPRY, and OTOGL. Each is linked with KCNQ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ2-to-partner and partner-to-KCNQ2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNQ2 versus MXRA5 in GBM, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ2→partner) and Y-score (partner→KCNQ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MXRA5 →	-1.774	-0.390	<.001	<.001	3	2
CCRCC	BSPRY →	+1.540	+1.902	.007	<.001	3	2
CCRCC	OTOGL →	+1.013	+1.626	.003	.001	3	2
CCRCC	HSD3BP2 →	+0.524	+1.218	.002	.002	3	2
CCRCC	RNU6-601P →	+1.524	+1.449	.002	.001	3	2
GBM	MIR657 →	+1.084	+0.371	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,685 associations by consensus.

KCNQ2 vs MXRA5 — GBM

Explore this scatter interactively →