KCNQ2

Across TCGA cell cohorts, KCNQ2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,890 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KCNQ2-associated GO terms across cancer lineages are Primary alcohol biosynthetic process, Aldosterone biosynthetic process, and Mineralocorticoid biosynthetic process. Each is linked with KCNQ2 in more than 8 cancer types. Because this analysis shows association rather than direction, both KCNQ2-to-partner and partner-to-KCNQ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Primary alcohol biosynthetic process grouped by KCNQ2-low versus KCNQ2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ2→partner) and Y-score (partner→KCNQ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Primary alcohol biosynthetic process →	-0.279	-2.564	<.001	<.001	3	9
SOFT_TISSUE	Aldosterone biosynthetic process →	+1.383	+2.901	<.001	<.001	3	8
SOFT_TISSUE	Mineralocorticoid biosynthetic process →	+1.329	+2.652	<.001	<.001	3	8
BONE	Blood coagulation, extrinsic pathway →	-1.455	-3.468	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Endocrine system development →	-0.067	-1.194	<.001	.006	2	7
BONE	Fat cell proliferation →	-0.406	-3.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,890 associations by consensus.

Primary alcohol biosynthetic process by KCNQ2 expression — SOFT_TISSUE

Explore this box plot interactively →