KCNQ2

Across TCGA cell cohorts, KCNQ2 mutation is significantly associated with the RNA expression of many other genes, with 376 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNQ2-associated genes across cancer lineages are TSPY10, H2AZ1, and PROP1. Each is linked with KCNQ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ2-to-partner and partner-to-KCNQ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY10 grouped by KCNQ2-low versus KCNQ2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ2→partner) and Y-score (partner→KCNQ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TSPY10 →	+0.226	+4.643	.002	.008	3	2
LARGE_INTESTINE	H2AZ1 →	+0.727	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	PROP1 →	+0.019	+2.469	<.001	<.001	3	2
LUNG_SCLC	SRARP →	+0.007	+3.099	.002	.003	3	1
LUNG_SCLC	HBD →	+0.102	+3.502	.001	.004	3	1
LUNG_SCLC	SMLR1 →	+0.149	+3.247	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 376 associations by consensus.

TSPY10 by KCNQ2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →