KCNQ1OT1

Across TCGA pan-cancer cohorts, KCNQ1OT1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KCNQ1OT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KCNQ1OT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNQ1OT1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where KCNQ1OT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNQ1OT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.236	<.001	11	view →
HNSC	Male	III,IV	+0.084	<.001	11	view →
LIHC	All	All	+0.035	<.001	7	view →
STAD	All	II,III,IV	+0.480	<.001	4	view →
CHOL	All	All	+0.330	.001	3	view →
BLCA	Female	All	+0.138	.032	3	view →
BRCA	All	All	+0.187	.021	2	view →
KIRP	Male	All	−0.153	<.001	2	view →
PAAD	All	All	+0.109	.044	2	view →
LUSC	All	All	+0.101	.005	2	view →
LUAD	All	All	+0.255	.023	1	view →
KIRC	Female	IV	−0.113	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KCNQ1OT1–COAD

Open the COAD breakdown →