KCNQ1

Across TCGA pan-cancer cohorts, KCNQ1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCNQ1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KCNQ1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNQ1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where KCNQ1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.240	0.968	.002	34	view →
PDAC	OS	Quartile	II,III,IV	0.879	0.229	.024	8	view →
CCRCC	DFS	Tertile	III,IV	0.822	0.527	.015	5	view →
UCEC	DFS	Tertile	All	0.739	1.000	.020	4	view →
LSCC	DFS	Tertile	II,III,IV	0.590	1.000	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCNQ1–LUAD (DFS)

Open the LUAD breakdown →