KCNQ1

Across TCGA patient cohorts, KCNQ1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNQ1-associated genes across cancer lineages are CDK1, STAT3_pY705, and ATM. Each is linked with KCNQ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNQ1-to-partner and partner-to-KCNQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by KCNQ1-low versus KCNQ1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ1→partner) and Y-score (partner→KCNQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDK1 →	+0.179	+3.321	.017	.009	3	3
SKCM	STAT3_pY705 →	-0.303	-3.321	.009	.009	2	3
UCEC	ATM →	-0.674	-2.571	<.001	.010	3	2
COAD	C-Raf →	+0.216	+3.008	.004	.019	2	3
COAD	Caspase-7-cleavedD198 →	+1.344	+3.008	.001	.019	3	2
SKCM	PI3K-p110-a →	+0.165	+3.017	.013	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

CDK1 by KCNQ1 expression — SKCM

Explore this box plot interactively →