KCNQ1

Across TCGA cell cohorts, KCNQ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,496 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNQ1-associated GO terms across cancer lineages are Regulation of atrial cardiac muscle cell membrane repolarization, Membrane repolarization during atrial cardiac muscle cell action potential, and Atrial cardiac muscle cell membrane repolarization. Each is linked with KCNQ1 in more than 11 cancer types. Because this analysis shows association rather than direction, both KCNQ1-to-partner and partner-to-KCNQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of atrial cardiac muscle cell membrane repolarization grouped by KCNQ1-low versus KCNQ1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ1→partner) and Y-score (partner→KCNQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of atrial cardiac muscle cell membrane repolarization →	-0.295	-1.528	<.001	<.001	3	12
LARGE_INTESTINE	Membrane repolarization during atrial cardiac muscle cell action potential →	+1.651	+2.527	<.001	<.001	3	11
LARGE_INTESTINE	Atrial cardiac muscle cell membrane repolarization →	+1.651	+2.527	<.001	<.001	3	11
BREAST	Positive regulation of cardiac muscle contraction →	-0.209	-1.190	<.001	<.001	3	9
STOMACH	Corticosteroid hormone secretion →	+1.495	+3.661	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Glyceraldehyde-3-phosphate metabolic process →	+0.060	+0.612	.005	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,496 associations by consensus.

Regulation of atrial cardiac muscle cell membrane repolarization by KCNQ1 expression — OESOPHAGUS

Explore this box plot interactively →