KCNQ1

Across TCGA cell cohorts, KCNQ1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNQ1-associated genes across cancer lineages are CABS1, RXFP2, and LORICRIN. Each is linked with KCNQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ1-to-partner and partner-to-KCNQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABS1 grouped by KCNQ1-low versus KCNQ1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ1→partner) and Y-score (partner→KCNQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CABS1 →	+0.096	+5.977	<.001	.001	3	1
LUNG_SCLC	RXFP2 →	+0.263	+4.044	<.001	.009	3	1
LUNG_SCLC	LORICRIN →	+0.032	+4.817	<.001	.001	3	1
LUNG_SCLC	SMIM9 →	+0.058	+4.817	<.001	.001	3	1
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
LARGE_INTESTINE	UCP1 →	+0.177	+2.923	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

CABS1 by KCNQ1 expression — SOFT_TISSUE

Explore this box plot interactively →